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KMID : 0606920170250020091
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Biomolecules & Therapeutics
2017 Volume.25 No. 2 p.91 ~ p.104
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Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders
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Kim Hyun-Pyo
Lim Hyun
Kwon Yong-Soo
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Abstract
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Acute bronchitis and chronic obstructive pulmonary diseases (COPD) are essentially lung inflammatory disorders. Various plant extracts and their constituents showed therapeutic effects on several animal models of lung inflammation. These include coumarins, flavonoids, phenolics, iridoids, monoterpenes, diterpenes and triterpenoids. Some of them exerted inhibitory action mainly by inhibiting the mitogen-activated protein kinase pathway and nuclear transcription factor-κB activation. Especially, many flavonoid derivatives distinctly showed effectiveness on lung inflammation. In this review, the experimental data for plant extracts and their constituents showing therapeutic effectiveness on animal models of lung inflammation are summarized.
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KEYWORD
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Medicinal plant, Lung inflammation, COPD, Constituent, Flavonoid
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